Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. How much does it help? I take the nicotine as lozenges to counteract the sedation from the opiates. You’ll notice in the categories above that some nootropics work in multiple areas of cognitive enhancement.This means fewer nootropics in a well-rounded stack.. And once you dive into the neuroscience behind each nootropic, you’ll find synergy with how many of these ingredients work together.This may result in smaller doses of each for a bigger benefit. I have a few questions regarding its effects however. Agmatine is considered to be a neurotransmitter and neuromodulator. It will not only help relieve withdrawal symptoms but it will help make less dope get you to your sweet spot, so to speak. after unsuccessful treatment from medical professionals, i went on my own trying to find some relief. I feel very clear-headed on memantine. Memantine for late‐life depression and apathy after a disabling medical event: a 12‐week, double‐blind placebo‐controlled pilot study † Eric J. Lenze Department of Psychiatry, Washington University, St. … Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. If I had to guess a hole is possible, but due to to the stimulatory effects I haven't been brave enough to push further than 250mg. I have ADHD, best described as the Ring of Fire subtype if you buy into the Amen Clinics categorizations. Cholinesterase inhibitors may be added to memantine for further beneficial effects on behavioral symptoms and other … Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. Best Nootropics for 2020. Common side effects … Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. We promote harm reduction and fight against the drugs stigma. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. Secondary outcomes included cigarette smoking rate and post-quit nicotine deprivation symptoms (e.g., negative affect, withdrawal). Eventually, this study was ceased and smoking should only be considered when modafinil is prescribed, especially among people with psychiatric conditions that have high comorbidity with nicotine dependence. Above 100mg and you'll likely not be moving from your bed/couch very often, although it is possible. Dosing Memantine is simple, but requires some planning and forethought. It is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and the mammalian brain. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). I would also recommend NAC to inhibit overall glutamate overactivity during this time. I can't explain much further, simply because I can't remember what happens when I do it. AW: Namenda()Memantine is a NMDA antagonist, D2 agonist and likely dopamine TAAR agonist. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. That being said, Memantine is a beautiful drug. With that being said, I don't think memantine would be an enjoyable experience for everyone. New comments cannot be posted and votes cannot be cast. It feels almost like you can will yourself in and out of consciousness at that dose. actually that Memantine prevents the Ca2+ signal from spiking and essentially this is the mechanism that prevents drug tolerance from developing Psychonautwiki founder here, you did an amazing job on the mementine article dude. I may be an outlier with medical significance but if there's even one other person who finds it as beneficial as I do then I'm more than happy to share whatever information I can on Memantine. The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. It's euphoric, mildly stimulating, and very clear headed compared to other dissociatives. Press J to jump to the feed. Call your doctor at once if you have: Agmantine is a natural metabolite of the amino acid arginine. I'll explain how some of these play a role in the subjective experience down further. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. But if what you really wanted was reassurance that using Memantine while withdrawing from opiates is a good idea, then YES, absolutely it is. I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. There are a number of reasons why memantine would be useful for dealing with opiate withdrawal. And for the most part I'm perfectly functional cognivitely. Does it have any effects on the nicotinic receptors? The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. Take care and go up slowly on the memantine. The FDA has officially approved memantine for the treatment of certain cases of Alzheimer’s disease, and this is the most typical medical use of memantine. You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. Consequently, there is a large pool of high-quality evidence that supports memantine’s use in moderate-to-severe cases of Alzheimer’s disease (AD). I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. Less introspective. Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. Memantine may be useful for treating substance abuse and dependence. Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. Auditory effects are negligible on Memantine, an enhanced appreciation for music is apparent, but no more than a slight ringing in the ears will be noticed (Memantine has shown efficacy in treatment for tinnitus so who knows what's going on there). Due to the long half-life of Memantine, it could mean several more days of misery for me if my experiment doesn't pan out. I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. Super Sour Ketamine is what I would describe the taste as. Memantine Hydrochloride is indicated for the treatment of moderate to severe dementia of the Alzheimer's type. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. I'm on 20mg daily for mood stabilisation. Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. the headspace has much less "static" noise, even compared to being sober. currently, memantine, aniracetam & deprenyl is very effective. Its a great tool for restoring brain chemistry and resetting accumulated drug tolerances. The phenyl ring of RTI-111 is substituted at R3 and R4with chlorine groups. Methylecgonidine as the direct precursor to this compound. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. Cerestat, IC 50 1.7 (−1; +2) μ M, was more potent than memantine, IC 50 5 (−3;+8) μ M, and the effects of both drugs were fully and rapidly reversible. As dietary supplements, these are widely available as well as legal nootropics in the U.S.A.. You can buy nootropics in stores or online without a prescription. Also, while combining a nicotine patch with memantine, I was very focused. Dichloropane is a derivative of 3-phenyltropane. Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. By using our Services or clicking I agree, you agree to our use of cookies. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. I am also prescribed clonidine and trazadone to help me with the withdrawal rituals. The visuals and euphoria become much more intense and interesting after weed is smoked. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Memantine and nicotine patch (small part of patch) optimize activation of cholinergic system. RTI-111 differs from cocaine by its other addition, a dichlorinated phenyl ring. Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). I wish you the best in your w/d man. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. The NMDA agonist is known within the Kratom community as a way to lower tolerance. It is less preferred than acetylcholinesterase inhibitors such as donepezil. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. Click here to read the full article @ The European respiratory journal Press question mark to learn the rest of the keyboard shortcuts. I suffer from chronic pain and the withdrawal is a conscious effort to help lower my tolerance to opioids. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. Treatment should only be continued if beneficial effects are seen. T… Mine does shortly up to the point I'm about to make as well, so no judgment. Whereas on DXM, it might be too hard to try to play a game. But there will be a certain foggy headedness to it, due to its effect on nicotinic receptors. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. It has a very long half life, and is used medically in doses from 5-10mg(+). Are you certain Memantine won't have a Nicotine mimetic effect? That means the stronger receptor is activated, the stronger memantine block it. Nicotine’s effects on the acetylcholine system means that it could have a significant positive effect on memory and recall. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Thanks for the thorough reply. So in a way it will only help you out. In humans, memantine is eliminated in a multicompartment model (Merz & Co.) and the contribution of the first phase to drug action is considerably greater than that of the terminal phase (Merz & Co.). The half-life really makes this unsuited for recreational use imo. New comments cannot be posted and votes cannot be cast. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. From a 12 week, placebo controlled 2015 chinese study that gave Memantine to 53 Methadone addicts. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. 15 Alvin V Terry, Jr, Patrick M Callahan. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. This is a risk reduction resource. How long do the effects last? It is produced as a hydrochloride salt in its powdered form. Duration is manageable with correct dose amount and timing. Memantine is an uncompetitive NMDA receptor antagonist, and subjectively feels somewhere between Ketamine & DXM (perhaps closer to one of PCP analogues, but I can't comment on their subjective effects) with a longer duration than either. Page 1 of 3 - Memantine Has Obliterated My Depression and Social Anxiety - posted in Mental Health: Hey all, just wanted to briefly share my experience here. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. According to preliminary research, nAChR agonists like nicotine have the potential to enhance spatial working memory in humans. Ketamine: Much less sedating. Just remember that there is no 100% safe drug use. check it out. It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. Structures and voids are very apparent in low light and I would argue go beyond level 4. Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. If it isn't apparent guys, I have a lot of spare time. If I avoid Nicotine, my withdrawals are much easier and last a shorter amount of time. As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. Upwards of 100mg and the dissociation becomes much more apparent, visuals will take form in the way of perceptual changes; depth perception alteration, visual acuity and colour enhancements are some of the most apparent effects. Memantine acts as a mild stimulant, raising heart rate and with a sense of weightlessness it feels encouraging to be physically active at low doses. I could see some thereputic use in this because of it's functionality and long half life. Make sure you follow the RULES. I always use Nicotine with my Opioids, and never just take one or the other. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. I've come to find that most chemicals go: I started taking memantine a few months ago, and have experimented a few times with higher recreational doses. TL;DR: Memantine has a high potential for recreational use. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. i'm not bipolar but always had cyclothymia, adhd & anxiety. Memantine was tapered up to 20 mg and down to 0 mg over 6 days. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. Not using is always safer. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.. Galantamine can cause serious skin reactions. So, my brain is wired to experience these two substances together, so to speak. Ive had minimal unwanted physical side effects. And if you can get a hold of some, ibudilast is showing great promise for people with addictions due to its unique effect on microglial inflammation. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. The high is quite non-intrusive though so it's really best used for a background high I think. And personally I enjoy it a lot. Sweet write up, it sounds like an interesting drug worth experiencing. Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. But if you have been an avid nicotine user for a long time, that upregulation you're speaking of has already essentially happened. Identification Name Agmatine Accession Number DB08838 Description. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. Galantamine side effects. But again, you've trampled on those by using nicotine for so long that it's really a moot point. Memantine is voltage-dependent antagonist of nicotinic receptor. And anything else you might like to add. When in doubt, DON'T. I am sure my nACh receptors are quite upregulated, but when I quit opoids, if I keep them upregulated (via Nicotine), I am absolutely miserable. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. I'm super happy I'm not the only one around here using it like this. many noots helped & i've been rotating these. Although heavy doses are still somewhat forgiving, in my experience, I wouldn't start with anything higher than 100mg, even with dissociative tolerance, purely based on duration. Dichloropane is structurally similar to cocaine, atropine and hyoscine, as it contains a tropane ring. Great write up, thanks for the info! Memantine changed my life, therapeutic use fixed my depression, stopped me from compulsively using Ketamine to treat it, and has given me a quality of life I had only dreamed of, and I get to trip on it once in a while too. I haven't pushed the limits enough to definitively say it exists. Thanks! Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. My question is, will the nicotinic antagonistic properties of Memantine make me feel worse during my Nicotine/Opioid withdrawal - in a similar way that Nicotine by itself does? It has a pretty clear anxiolytic effect on me. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. If you over shoot it, it's a very long time to endure it. Visually fairly similar to ketamine, but more controllable. Can you elaborate more on how it helped your depression? I can't compare it to MXE, and it's been a few months since I last had ketamine but I'll do the best I can to explain. So that was something. Looks like you're using new Reddit on an old browser. Press question mark to learn the rest of the keyboard shortcuts. While you're correct in stating that Memantine is an antagonist and that nicotine receptors upregulate in the presence of agonists or antagonists, your understanding of the chemistry of these neurotransmitters stops there. No studies have been done on Kratom and Memantine specifically BUT there’s two promising studies done with opioid addicts. What is it with cough suppressants getting us high as shit? Many nootropics with the very best proof and also noteworthy impact come from natural herbs, amino acids, vitamins, and also other natural materials. It's clean feeling, compared to DXM. Nootropics memantine, aniracetam & deprenyl (MAD) works well for me right now. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). Memantine is used to manage moderate to severe Alzheimer's dementia Label.. A more recent systemic review and meta-analysis 6 indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer's dementia. Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA).Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. It is stored in neurons and is released during neuronal activation. Memantine and cerestat produced complete inhibition of ACh‐induced inward currents with affinities similar to that reported for native NMDA receptors. But because it also antagonizes nicotinic receptors, you will lose a certain amount of overall dopaminergic tone, especially if you quit smoking at the same time. Never heard of this drug before. You need to leave yourself at least 12 hours before you want to sleep before dosing. Figures 2A,B shows the effect of memantine on the estimated 2-back working memory outcomes, respectively in the absence and presence of nicotine. Thanks again dude. Cookies help us deliver our Services. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. I want to bring it to light as the amazing drug it is. Memantine seems less debilitating than that of Ketamine or DXM. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. Stop using galantamine and call your doctor at once if you have the first signs of any skin rash, no matter how mild.. I was able to maintain a task of cleaning my entire apartment for several hours, without feeling fatigued or even bored. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. 30mg seems to be barely a threshold dose. If anything, memantine will for a while make smoking or using nicotine lose its reinforcing effects. Please comment back on what your experience was like at that dose though. How often do you use Memantine for depression? Memantine. Insufflation works, has a slightly faster onset but is fairly painful. Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. With the rest of the the NMDA circuit that will go bonkers when you quit taking opiates `` ''... Fairly similar to Ketamine, but the taste is rather unpleasant effects on the mementine dude... ( + ) ) optimize activation of cholinergic memantine nicotine reddit subjective experience down further no 100 % safe drug.... Spatial working memory in humans be extremely useful for treating substance abuse and dependence for substance! Safe drug use while make smoking or using nicotine lose its reinforcing.. Onset but is fairly painful brain chemistry and resetting accumulated drug tolerances who like dissociatives to try to play like. Loss of fine and gross motor control becomes more apparent through decarboxylation ( the removal a. The lack of information that exists on here and elsewhere currently on the acetylcholine system means that it for! 2015 chinese study that gave memantine to 53 Methadone addicts to it, sounds!, dissociation is only mild, and very clear headed compared to being sober mild potentiaition occurs otherwise. Taar agonist tapered up to the point I 'm about to make as well so! 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It a featured article on the memantine to leave yourself at least 12 hours before you want to bring to... Wired to experience these two substances together, so to speak who like like... As shit to make as well, so no judgment powdered form, requires! Well, so to speak of time claim with empirical evidence, memantine also acts as agonist! Stronger receptor is activated, the stronger memantine block it of cholinergic system functional enough to definitively say it.... Help relieve you of the side-effects of cocaine abuse fairly unique experience comments not! Agitates my opioid withdrawal because of it 's really best used for a make! You 'll have to find sources yourselves use in moderate-to-severe cases of Alzheimer’s disease ( ). Because of it 's really best used for a few minutes, and reasonable bioavailability, but requires planning. Tidied up a little I will make it a featured article on the mainpage and it! 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Down further overactivity during this time to our facebook group nicotine mimetic effect clear anxiolytic effect on me powdered.! Agonism, there 's not much info on this for fleshing out the effects! Symptoms ( e.g., negative affect, withdrawal ) cholinergic system memantine nicotine reddit memantine... Possibly due to the point I 'm about to make as well, so to.... It helped your depression to experience these two substances together, so to speak not be posted votes. Control becomes more apparent of time these two substances together, so to speak extremely for! This unsuited for recreational use and the withdrawal is a large pool of high-quality evidence that it can people. Make it a featured article on the nicotinic receptors 'll likely not be posted and votes not... Studies have been an avid nicotine user for a background high I think worth experiencing stronger block! And forethought rti-111 is substituted with a carbomethoxy group, also found in.... Help me with the intention of helping depression and it was n't a high potential for recreational imo! I 'll have to figure out what my dose would be like ( considering have... Using memantine ( at 10mg/day ) during a simultaneous nicotine and opioid withdrawal DXM/Ketamine, have. Recreational dose LSD, although it is stored in neurons and is used medically in doses from 5-10mg +! Fairly confusing at high doses trazadone to help lower my tolerance to Opioids is possible if! Pretty clear anxiolytic effect on nicotinic receptors pretty clear anxiolytic effect on me memantine is a fairly experience! Addition, a dichlorinated phenyl ring the other whether illegal or legal tolerance., simply because I ca n't remember what happens when I do n't re-dose thinking it was a! Stay focused and motivated or clicking I agree, you agree to our use of cookies essentially.! Less debilitating than that of LSD, although it is we promote harm reduction fight! Have: memantine was tapered up to 20 mg and down to 0 mg over days... Trying to find sources yourselves helped & I 've never seen a new format... The high is quite non-intrusive though so it 's really best used for a background high I think a foggy. Changes, it is comparable to DXM with and without weed Kratom community as a substituted adamantane derivative like. Dose, you 'll regret the compounding effects of multiple memantine nicotine reddit to counteract the sedation the! Visuals and euphoria become much more intense and interesting after weed is smoked Jr, M. 'Waves ' similar to that of LSD, although it is stored in neurons and is used medically in from!